Association of Interleukin-6 with lipid peroxidation and serum lipids in primary hypertension [dataset]

Iosr Journals, Vijaya Bhaskar.M, Balu Mahendran.K
2015 Figshare  
Inflammatory mechanisms play a key role in the pathogenesis of systemic diseases associated with metabolic syndrome or its components such as obesity, insulin resistance, hypertension and atherogenic dyslipidemia. Elevated levels of interleukin-6 (IL-6), a key pro-inflammatory cytokine has been shown to be associated with increased future risk of vascular complications. Aim: The aim of this study was to evaluate the significance of IL-6 levels in hypertensive patients compared with controls and
more » ... d with controls and to determine the association of IL-6 with lipid peroxidation marker (malondialdehyde) and serum lipids. Materials and methods: Thirty hypertensive patients with the age group of 30 to 50 years were selected for this study and 30 healthy age and sex matched subjects were selected as control group. Serum IL-6 was assessed by ELISA, malondialdehyde (MDA) was assessed by Thiobarbituric Acid Reactive Substances (TBARS) method and all other investigations were done by ERBA EM-360 fully automated analyzer. Results: The mean levels of serum IL-6 was significantly increased in hypertensive patients compared with controls. Serum IL-6 levels were positively correlated with malondialdehyde, Cholesterol, TGL, LDL and negatively correlated with and HDL. Conclusion: Serum IL-6 might be potentially useful diagnostic marker for the severity of inflammation and also a pathogenic cofactor contributing to chronicity of the disease and vascular complications.
doi:10.6084/m9.figshare.1464936.v1 fatcat:6ckem4ruwbbizkq6qtb2awucy4