A hybridisation-dependent membrane-insertable amphiphilic DNA

C. Dohno, K. Matsuzaki, H. Yamaguchi, T. Shibata, K. Nakatani
2015 Organic and biomolecular chemistry  
We synthesized a new class of membrane-binding amphiphilic DNA consisting of hydrophilic phosphodiester-linked DNA and hydrophobic octyl phosphotriester-linked DNA. The amphiphilic DNA binds to the lipid membrane by inserting the hydrophobic region, which is facilitated by the presence of the complementary DNA strand.
doi:10.1039/c5ob01761k pmid:26369435 fatcat:gu5twgf7hban3i4bnofehjd33i