Concerta cf Ritalin Effects on Driving Performance

J Gordon Millichap
2004 Pediatric Neurology Briefs  
The effect of low neonatal cerebral blood flow (CBF) on dopaminergic neurotransmission was studied in 6 genetically susceptible high-risk, preterm neonates followed with attention deficit hyperactivity disorder (ADHD) at Aarhus University Hospital, Denmark, and tested at 12-14 years of age. The authors hypothesized that cerebral ischemia at birth might contribute to deficient dopaminergic neurotransmission, which is considered to be the basis for ADHD. Dopamine receptor binding in the striatum
more » ... ng in the striatum was examined with positron emission tomography (PET), and inattention and impulsiveness were measured by continuous reaction times (RT) and RT variability determined by a computerized test of variables (TOVA). In 6 adolescents (12-14 years of age; 5 boys) with CBF measurements at preterm birth and a subsequent diagnosis of ADHD, high striatal dopamine receptor availability ('empty receptors') was correlated with increased RT and RT variability, findings that supported a dopaminergic role in ADHD symptomatology. The link demonstrated between high dopamine receptor availability with low neonatal CBF supports the hypothesis of cerebral ischemia as a risk factor for ADHD. (Lou HC, Rosa P, Pryds 0 et al. ADHD: increased dopamine receptor availability linked to attention deficit and low neonatal cerebral blood flow.
doi:10.15844/pedneurbriefs-18-3-8 fatcat:tptuxlqoq5ddfkytyyngtj3fgm