Giant cell angiofibroma of the oral cavity: A case report and review of the literature

Cleverton Roberto de Andrade, Márcio Ajudarte Lopes, Oslei Paes de Almeida, Jorge Esquiche León, Florence Mistro, Sergio Kignel
2008 Medicina Oral  
Giant cell angiofibroma is a well-circumscribed, normally encapsulated, distinctive orbital soft tissue tumor. However, it is now recognized that this lesion can also present in other locations, including the oral cavity. The morphological hallmark is a richly vascularized, patternless spindle cell proliferation containing pseudovascular spaces and floret-type multinucleate giant cells. CD34 immunoreactivity, although not specific, represents the only immunohistochemical finding of potential
more » ... ing of potential diagnostic value. We present a case of a 44-year-old male Caucasian patient complaining of painless solitary nodule arising on the right buccal mucosa, which was diagnosed as giant cell angiofibroma. To the best of our knowledge, this is the third case of oral giant cell angiofibroma reported in the English-language literature.
pmid:18758395 fatcat:5gugwvta5rfodoniju4hourqoe