The Role of the Aerobic Microflora in the Genesis of Fatty Acids in Human Surface Lipids**From the Department of Dermatology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 and the Departments of Dermatology and Biochemistry, Boston University School of Medicine, Boston. Massachusetts 02118.‡

Richard R. Marples, Albert M. Kligman, Larry R. Lantis, Donald T. Downing
1970 Journal of Investigative Dermatology  
The aerobic microflora of the scalp, predominantly cocci, wa virtually eliminated by the daily application of 1 o/o aqueous neomycin for one month. This was done to test whether these organisms are an important source of the lipases which liberate fatt:y acid from the sebaceous triglycerides. This treatment had no effect on the proportion of fre fatty acids in the urface lipids as determined by thin layer chromatography . The follicle-residing anaerobic C. acnes, was not attacked by neomycin
more » ... the yeast-like fungus P. ovale increased somewhat. The percentage of free fatty acids in any individual's sebum before and after treatment was positively correlated with the density of C. acnes. The latter oro-:mi"m is probably mainly respon ible for lipol:v i of triglycerides.
doi:10.1111/1523-1747.ep12280672 pmid:5466700 fatcat:oonb4fyleffitf3bjuef4qlhbe