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INTRODUCTION: Cognitive decline in Alzheimers disease is associated with amyloid-β accumulation, neurodegeneration and cerebral small vessel disease, but the temporal relationships between these factors is not well established. METHODS: Data included white matter hyperintensity (WMH) load, grey matter (GM) atrophy and Alzheimers Disease Assessment Scale-Cognitive-Plus (ADAS13) scores for 720 participants and cerebrospinal fluid amyloid (Aβ1-42) for 461 participants from the Alzheimers Diseasedoi:10.1101/2020.05.27.119586 fatcat:w4cyflshy5amjfsnemlbguvtxu