The Temporal Relationships between White Matter Hyperintensities, Neurodegeneration, Amyloid β, and Cognition [article]

Mahsa Dadar, Richard Camicioli, Simon Duchesne, D. Louis Collins
2020 bioRxiv   pre-print
INTRODUCTION: Cognitive decline in Alzheimers disease is associated with amyloid-β accumulation, neurodegeneration and cerebral small vessel disease, but the temporal relationships between these factors is not well established. METHODS: Data included white matter hyperintensity (WMH) load, grey matter (GM) atrophy and Alzheimers Disease Assessment Scale-Cognitive-Plus (ADAS13) scores for 720 participants and cerebrospinal fluid amyloid (Aβ1-42) for 461 participants from the Alzheimers Disease
more » ... uroimaging Initiative. Linear regressions were used to assess the relationships between baseline WMH, GM, and Aβ1-42 to changes in WMH, GM, Aβ1-42, and cognition at one-year follow-up. RESULTS: Baseline WMHs and A-β predicted WMH increase and GM atrophy. Baseline WMHs, GM, and A-beta1-42 predicted worsening cognition. Only baseline A-beta predicted change in A-β. DISCUSSION: Baseline WMHs lead to greater future GM atrophy and cognitive decline, suggesting that WM damage precedes neurodegeneration and cognitive decline. Baseline A-β1-42 predicted WMH increase, suggesting a potential role of amyloid in WM damage.
doi:10.1101/2020.05.27.119586 fatcat:w4cyflshy5amjfsnemlbguvtxu