Acute Pancreatitis Associated with Hemorrhagic Fever with Renal Syndrome: A Cohort Study of 346 Patients [post]

Qinyue Guo, Bin Du, Jing Xu, Qindong Shi
2020 unpublished
Background: Acute pancreatitis is one of the rare complications of hemorrhagic fever with renal syndrome (HFRS), usually ending with high mortality rate and severe prognosis. In this study, we retrospectively analyzed to explore the risk factors, clinical characteristics, and outcomes in totally 346 patients with HFRS.Methods: We retrospectively reviewed the 358 cases diagnosed with HFRS from January 2013 to July 2020, including 29 cases complicated with acute pancreatitis (AP). Clinical
more » ... tion and laboratory parameters were obtained by Hospital Information System. The characteristics and clinic outcomes between the HFRS group and HFRS-AP group were compared by multivariate analysis and a nested case-control study, respectively.Results: 346 eligible patients diagnosed with HFRS, of which 29 (8.38%) developed acute pancreatitis. While 19 (65.5%) were male, 10 (34.5%) were female. The mean age was 44.38 years. For life style analysis, 11 (37.9%) of 29 exhibited a habit of smoking, and 9 (31.0%) exhibited drinking. The 90-day mortality was 7 (24.14%) for the HFRS+AP patients and 7 (2.21%) for the HFRS patients (p < 0.001). Multivariate analysis indicated that HFRS patients, who confirmed AP, were associated with increased mortality (aOR:17.60; 95% CI, 4.3–73.3) and other poor prognoses; the same trend was shown in propensity matched data. Liver function and inflammatory parameters (except procalcitonin) were expressed much worse in AP patients (p < 0.05, respectively). Serum calcium shown a negative correlated with AP patients (p < 0.05).Conclusions: Our study indicates that patients with HFRS-AP are significantly associated with higher mortality and poor prognoses, it should be alert and complete necessary test for properly diagnosis on admission. In future, cohort study and randomized control trail are highly required for the best treatment of HFRS-AP.
doi:10.21203/rs.3.rs-100709/v1 fatcat:5pycgui3irgwnevyhuaajscr4i