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Functional Dichotomy of Protein Kinase C (PKC) in Tumor Necrosis Factor-α (TNF-α) Signal Transduction in L929 Cells
2000
Journal of Biological Chemistry
Tumor necrosis factor-␣ (TNF-␣) is capable of inducing a variety of biologic responses through multiple signaling pathways. Because of the potential role of protein kinase C (PKC) in apoptosis, we examined the effects and mechanisms of TNF-␣ on PKC regulation, specifically on PKC␣. In L929 murine fibroblasts, TNF-␣ (0.5-5 nM) caused potent inhibition of PKC␣ activity and induced translocation of PKC␣ from the cytosol to the membrane. Treatment of cells with TNF-␣ also induced dephosphorylation
doi:10.1074/jbc.m000170200
pmid:10887171
fatcat:w6mmep4lpvh3pa4aqz674uclv4