The fracture risk assessment tool (FRAX® score) in subclinical hyperthyroidism

Snezana Polovina, Dragan Micic, Dragana Miljic, Natasa Milic, Dusan Micic, Vera Popovic
2015 Vojnosanitetski Pregled  
Background/Aim. The Fracture Risk Assessment Tool (FRAX ® score) is the 10-year estimated risk calculation tool for bone fracture that includes clinical data and hip bone mineral density measured by dual-energy x-ray absorptiometry (DXA). The aim of this cross-sectional study was to elucidate the ability of the FRAX ® score in discriminating between bone fracture positive and negative pre-and postmenopausal women with subclinical hyperthyroidism. Methods. The bone mineral density (by DXA),
more » ... sity (by DXA), thyroid stimulating hormone (TSH) level, free thyroxine (fT4) level, thyroid peroxidase antibodies (TPOAb) titre, osteocalcin and beta-cross-laps were measured in 27 pre-and postmenopausal women with newly discovered subclinical hyperthyroidism [age 58.85 ± 7.83 years, body mass index (BMI) 27.89 ± 3.46 kg/m 2 , menopause onset in 46.88 ± 10.21 years] and 51 matched euthyroid controls (age 59.69 ± 5.72 years, BMI 27.68 ± 4.66 kg/m 2 , menopause onset in 48.53 ± 4.58 years). The etiology of subclinical hyperthyroisims was autoimmune thyroid disease or toxic goiter. FRAX ® score calculation was performed in both groups. Results. In the group with subclinical hyperthy-Correspondence to: Vol. 72, No 6 VOJNOSANITETSKI PREGLED Page 511 0,50 ± 0,46, p= 0,022) bio je značajno veći u grupi sa supkliničkim hipertireoidizmom u odnosu na kontrolnu grupu. Nije bilo korelacije između nivoa TSH i rizika od frakture (p > 0,05). Kompetentnost skora FRAX ® u razlikovanju pre-i postmenopauzalnih žena sa rizikom od frakture i bez rizika (p < 0.001) je prikazana površinom ispod krive (AUC) pomoću ROC analize. Cut-off vrednost skora FRAX ® bila je u ovoj analizi 6%, sa pretpostavljenom senzitivnošću i specifičnošću od 95% i 75,9%. Zaključak. Pre-i postmenopauzalne žene sa supkliničkim hipertireoidizmom imaju veći skor FRAX ® i time veći rizik od preloma kuka na malu traumu nego eutireoidne žene. Naši rezultati ukazuju na to da primena FRAX ® kalkulatora u grupi pre-i postmenopauzalnih žena sa supkliničkim hipertireoidizmom doprinosi prepoznavanju osoba sa povećanim rizikom od preloma kostiju.
doi:10.2298/vsp1506510p pmid:26226723 fatcat:yw35l5hmrbfd5d6aamskjvzel4