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Herpes simplex virus type 2 inhibition of Fas ligand expression
1996
Journal of Virology
Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are common human pathogens. In this report we demonstrate the capacity of HSV-2, but not HSV-1, to inhibit the activity and cell surface expression of Fas ligand, an important molecule involved in T-cell apoptosis and cell-mediated cytotoxicity. Cells infected with HSV-2 retained Fas ligand intracellularly instead of expressing it on the cell surface. Addition of anti-Fas antibodies markedly inhibited HSV-2 viral production, suggesting that
doi:10.1128/jvi.70.12.8747-8751.1996
fatcat:4wihvufyhnaerd6tej7k3fwapu