The Effects of Calcium and Potassium Ions on Urine Secretion, as Studied in the Whole Animal

L. Brull, F. Eichholtz
1925 Proceedings of the Royal Society of London. Biological Sciences  
From the Physiology In stitu te , U niversity College, London.) In a previous paper Eichholtz and Starling (1) have described the effect of Ca and K ions on the kidney connected with the heart-lung preparation. They have shown that these salts, when acting together, have definite results on the volume and the composition of the urine yielded by the isolated gland.. These effects are :- (1) Increase of urine flow. (2) Increase of Cl percentage in the urine up to the chloride level of the serum.
more » ... evel of the serum. (3) Stoppage of the inorganic P excretion produced by the injection of inorganic P. Attempts have been made to see whether and to what extent these state ments can be confirmed on the whole animal. Thirty-five experiments have been performed. Methods. Our experiments were performed on dogs, anaesthetized by morphia and chloralose. A little chloroform-ether was given until the chloralose was injected. The animals were on a variable diet before the experiments. Blood pressure was measured from the carotid, urine flow by catheterizing both ureters separately. In all experiments the left kidney was denervated from the back. When the pituitary body was removed, the way of approach was the temporal one. The chemical determinations were performed according to the methods mentioned in Starling and Verney's paper (2). E xperimental R esults. Two points are to be considered in this paper, viz. :- (1) Effect on water output. (2) Effect on chloride percentage. Since in most cases these elements seem to behave independently, we shall deal with them singly. The question of the phosphate output in the whole on July 20, 2018 Downloaded from
doi:10.1098/rspb.1925.0068 fatcat:6c7ptjrqcncxlmuz4i42hrjqzi