Investigating Process Variables and Additive Selection To Optimize Polymorphic Control of Carbamazepine in a CO2 Antisolvent Crystallization Process [component]

Supercritical CO 2 antisolvent crystallization typically promotes the formation of metastable polymorphic forms of pharmaceutical drugs. However, using this technological approach in combination with the use of distinct molecular additives can provide further control over the final polymorphic form obtained. The work presented herein investigates the influence of critical processing variables of a CO 2 antisolvent crystallization process in the presence of molecular additives with respect to
more » ... ymorphism of carbamazepine (CBZ), a highly polymorphic BCS class II drug. A Design of Experiments (DoE) approach was performed to
doi:10.1021/acs.oprd.9b00545.s001 fatcat:sf7aq47xgvaxbem5g32nbipuh4