Vulvovaginal Chronic Graft-Versus-Host Disease With Allogeneic Hematopoietic Stem Cell Transplantation

Pamela Stratton, Maria L. Turner, Richard Childs, John Barrett, Michael Bishop, Alan S. Wayne, Steven Pavletic
2007 Obstetrics and Gynecology  
OBJECTIVE: To describe the diagnosis and management of female genital chronic graft-versus-host (GVH) disease, a complication of hematopoietic stem cell transplantation. METHODS: From 1999 to 2006, 33 women with vulvar symptoms or undergoing systematic evaluation for chronic GVH disease were referred 267 (median, range 29 -6,117) days after transplantation for gynecologic evaluation. Pertinent histories, laboratory tests, and skin and genital area-directed examinations were performed. Vulvar
more » ... erformed. Vulvar disease was treated with superpotent topical glucocorticoids and topical estrogen. Sexually active, menopausal women used vaginal dilators, topical glu-cocorticoids and estrogen, and estrogen vaginal rings for vaginal synechiae.
doi:10.1097/01.aog.0000285998.75450.86 pmid:17978118 fatcat:p6rrjbn3ojdvbpdetl63lt35k4