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This chapter provides an overview of the data supporting the role for pharmacotherapy in the treatment of alcohol dependence. Drugs acting on several brain neurotransmitters systems including dopamine, serotonin, GABA, glutamic acid and opioid systems are under investigation. Disulfiram, naltrexone and acamprosate are the drugs most commonly used during the rehabilitation period. Disulfiram seems to be effective mostly when given under supervision. In the case of acamprosate and naltrexone, thedoi:10.20882/adicciones.537 fatcat:faxvt64cknhcxj3nnaavevgdyy