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Toward a rapid and accurate point-of-care test for active pulmonary tuberculosis: Multiplexed proteomic assay (SOMAscan™) of human serum for microbial and host markers
International Journal of Infectious Diseases
A rapid, accurate, and inexpensive tuberculosis (TB) diagnostic test would allow earlier treatment and reduce transmission. Methods & Materials: We used slow off-rate modified aptamers (SOMAmers) in a highly multiplexed proteomic assay (SOMAscan) to measure 1129 human proteins and 16 Mtb proteins in serum samples provided by the Foundation for Innovative New Diagnostics (FIND). Results: Among the top host serum biomarkers distinguishing TB from non-TB regardless of the HIV status weredoi:10.1016/j.ijid.2014.03.1172 fatcat:mzqbzc3bnjbwzeeavhgsq4axjy