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There is now a large literature implicating cytokines in the development of wasting and cachexia commonly observed in a variety of pathophysiologic conditions. In the acquired immunodeficiency syndrome (AIDS), cytokines elicited by primary and secondary infections seem to exert subtle and sustained effects on behavioral, hormonal, and metabolic axes, and their combined effects on appetite and metabolism have been postulated to drive wasting. However, correlations of increased blood levels of adoi:10.1016/s0899-9007(98)00108-7 pmid:9834928 pmcid:PMC7135128 fatcat:ewg7wvdfovd4bk73zdvsatzcny