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Bimolecular Interaction of Insulin-Like Growth Factor (IGF) Binding Protein-2 with αvβ3 Negatively Modulates IGF-I-Mediated Migration and Tumor Growth1
Both the integrin and insulin-like growth factor binding protein (IGFBP) families independently play important roles in modulating tumor cell growth and progression. We present evidence for a specific cell surface localization and a bimolecular interaction between the ␣v␤3 integrin and IGFBP-2. The interaction, which could be specifically perturbed using vitronectin and ␣v␤3 blocking antibodies, was shown to modulate IGF-mediated cellular migration responses. Moreover, this interaction wasdoi:10.1158/0008-5472.can-03-3056 pmid:14871828 fatcat:6ub3nlh7x5fohernqpmgwubit4