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The Vesicular Acetylcholine Transporter Is Required for Neuromuscular Development and Function
2009
Molecular and Cellular Biology
The vesicular acetylcholine (ACh) transporter (VAChT) mediates ACh storage by synaptic vesicles. However, the VAChT-independent release of ACh is believed to be important during development. Here we generated VAChT knockout mice and tested the physiological relevance of the VAChT-independent release of ACh. Homozygous VAChT knockout mice died shortly after birth, indicating that VAChT-mediated storage of ACh is essential for life. Indeed, synaptosomes obtained from brains of homozygous
doi:10.1128/mcb.00245-09
pmid:19635813
pmcid:PMC2747982
fatcat:phkwcvjwrfh2hns4egicjm5uki