A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf
.
Selection of protein conformations for structure-based polypharmacology studies
2018
Drug Discovery Today
Teaser This review will focus on currently available methods for the selection of the most suitable protein conformations for multi-target structure-based drug design. Highlights Structure-based approaches play a central role in polypharmacology drug design. Similar protein conformations are able to accommodate similar ligands. The use of selected protein conformations affects structure-based drug design results. In silico approaches for protein conformation selection are presented.
doi:10.1016/j.drudis.2018.08.007
pmid:30099123
fatcat:wg2x3d6nk5budkn6iuc23hopbe