Bhagandara (fistula-in-ano) is a disease which is pertaining to anorectal region which is a highly prevalent disease among the anorectal diseases. Acharya Sushruta considered it as one among the Ashtamahagadas. There is a wide description of its etiology, pathogenesis, types, Sadhyasadhyata, various modality of treatment, Pathya and Apathya in various classical texts. Ayurveda classics have explained different types of Bhagandara and its Chikitsa which includes medical, surgical alternative and

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... surgical management. The modern medical system treats the condition using seton technique or surgery. The Ksharasootra method explained in Ayurveda Samhitas believed to have more efficacy than the seton technique. The incidence of fistula-in-ano is increasing gradually irrespective of age and sex. It affects the day-to-day life of the patients with its severity in presentation. Here a case study is discussed in which the patient suffered from multiple fistula-in-ano, was treated with Teekshna Apamarga Ksharasootra and internal medications. Fistula got completely cured in 6 months without recurrence in 1 year follow up.