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MultiSig: a new high-precision approach to the analysis of complex biomolecular systems
2013
European Biophysics Journal
MultiSig is a newly developed mode of analysis of sedimentation equilibrium (SE) experiments in the analytical ultracentrifuge, having the capability of taking advantage of the remarkable precision (*0.1 % of signal) of the principal optical (fringe) system employed, thus supplanting existing methods of analysis through reducing the 'noise' level of certain important parameter estimates by up to orders of magnitude. Long-known limitations of the SE method, arising from lack of knowledge of the
doi:10.1007/s00249-013-0924-y
pmid:23989852
pmcid:PMC3824846
fatcat:vlbmu4kud5g5rf2wv73e4uknci