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Isotretinoin is considered a gold standard in treating severe cases of acne. It brings lots of benefits but on the other hand can cause series of undesirable side-effects. I present 2 cases of patients suffering from acne fulminans in the course of treatment with oral isotretinoin. Acne fulminans is a very severe systemic disease and its course is difficult to foresee. The most important is rapid diagnosis and implementation of treatment. Systemic corticosteroids combined with isotretinoin ordoi:10.7241/ourd.20172.57 fatcat:nc5g3uwpszd2rjjziplaumn4qu