Comparison of the Sedative Effect of Ketofol and The Combination of Midazolam-Ketamine in Upper GI Tract Endoscopy in 1-14 Years Childeren
Journal of Ardabil University of Medical Sciences
& objectives: Endoscopy is an invasive and painful procedure. The use of sedatives, especially in children, is expanding. The aim of this study was to compare the sedative effects of ketofol and the combination of midazolam-ketamine in upper GI endoscopy in children aged 1 to 14 years who referred to Taleghani Hospital in the city of Gorgan. Methods: In this study, 55 children 1 to 14 years old entered the study after obtaining parental consent. They were divided into two groups,
... ups, ketamine-propofol (KP) and ketaminemidazolam (KM), by simple randomization. At all stages of the work, patients underwent cardiac and respiratory monitoring. All hemodynamic parameters and ramsay sedation score (RSS) were recorded for all participants in the 5 time periods before, during and after endoscopy. ANOVA test and bonferroni tracking test were used in SPSS software to analyze and compare data. Results: 54.5% were male patients. The ANOVA test showed that the scores of the two groups at the time of the study had a statistically significant difference (p=0.02). In the KM group, the mean blood pressure and heart rate of patients increased at all times compared to before the intervention (p=0.005). Blood pressure in the KP group had a steady trend over time (p<0.001). Conclusion: There was a statistically significant difference between the scores of the two groups and the group (KM) had higher scores, but the use of two drug regimens Propofol-Ketamine and Ketamine-Midazolam caused a good sedation in pediatric endoscopy. The propofol-ketamine compound resulted in greater hemodynamic stability in cardiovascular parameters during and after endoscopy.