ISOLATION OF ANTIFUNGAL QUINOID DERIVATIVES FROM LEAVES OF Pentacalia desiderabilis (Vell.) Cuatre. (Asteraceae) USING IONIC LIQUID IN THE MICROWAVE ASSISTED EXTRACTION

Kaio Gomes, Cinthia Tamayose, Marcelo Ferreira, Cynthia Murakami, Maria Claudia Young, Guilherme Antar, Fernanda Camilo, Patricia Sartorelli, João Henrique Lago
2018 Química Nova  
publicado na web em 20/12/2018 In the present work, leaves of Pentacalia desiderabilis (Asteraceae) were subjected to extraction using aqueous 1-butyl-3methylimidazolium bromide (BMImBr) in the microwave assisted extraction (MAE). The obtained extract was partitioned using CH 2 Cl 2 and antifungal activity against Cladosporium cladosporioides and C. sphaerospermum of the organic phase was evaluated. Sequentially, this material was subjected to several chromatographic procedures to afford four
more » ... es to afford four quinoid derivatives identified as jacaranone (1) , methyl-jacaranone (2), quinolacetic acid (3) , and methyl 1-hydroxy-4-oxo-cyclohexaneacetate (4), being the first occurrence of compounds 2 -4 in P. desiderabilis. Isolated quinoid derivatives were submitted to bioautography assay and the obtained results indicated that compounds 1 -3 are active against Cladosporium cladosporioides (0.78, 12.5 and 12.5 μg, respectively) and C. sphaerospermum (3.13, 12.5 and 12.5 μg, respectively).
doi:10.21577/0100-4042.20170319 fatcat:yqvxoek3vfgjzd4tlmxp5slkay