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Whole genome sequencing detects minimal clustering among Escherichia coli Sequence Type 131 H30 isolates collected from U.S. children's hospitals [article]

Arianna Miles-Jay, Scott J. Weissmann, Amanda A. Adler, Janet G. Baseman, Danielle M. Zerr
2019 medRxiv   pre-print

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Escherichia coli sequence type 131 H30 has garnered global attention as a dominant antimicrobial-resistant lineage of extraintestinal pathogenic E. coli, but its transmission dynamics remain undefined. We applied whole genome sequencing to identify putative transmission clusters among clinical isolates of H30 from children across the U.S. Of 126 isolates, 17 were involved in 8 putative transmission clusters; 4 clusters involved isolates with some evidence of healthcare-associated epidemiologic
more » ... inkages. Geographic clustering analyses showed weak geographic clustering. These findings are consistent with a framework where within-hospital transmission is not a main contributor to the propagation of H30 in a pediatric setting.
doi:10.1101/19010140 fatcat:w6f7wa7u5zhyxfad2mcs5ngjiu
Citation

Arianna Miles-Jay, Scott J. Weissmann, Amanda A. Adler, Janet G. Baseman, Danielle M. Zerr. "Whole genome sequencing detects minimal clustering among Escherichia coli Sequence Type 131 H30 isolates collected from U.S. children's hospitals." medRxiv (2019)