Bioactive Eudesmane sesquiterpenes from Artabotrys hongkongensis Hance

Qing Wen, Yan-Ping Liu, Gui Yan, Shuo Yang, Shi Hu, Jing Hua, Wen-Qing Yin, Guang-Ying Chen, Yan-Hui Fu
2019 Figshare  
A new naturally occurring trinoreudesmane sesquiterpene, artahongkongol A (1), together with seven known eudesmane sesquiterpenes (2−8), was isolated from the stems and leaves of Artabotrys hongkongensis Hance. Among them, 1 is a rare trinoreudesmane sesquiterpene containing 12 carbon atoms on the carbon skeleton. All known compounds (2−8) were isolated from the genus Artabotrys for the first time. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were
more » ... nown compounds were identified by comparisons with data reported in the literature. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1−8 showed significant inhibitory effects against various human cancer cell lines with IC50 values ranging from 0.57 to 15.68 μM.
doi:10.6084/m9.figshare.7792085 fatcat:y564oii5urbgpn7xrtitx7gxdq