Cancer chemoprevention activity of labdane diterpenes from rhizomes of Hedychium coronarium

Denise C. Endringer, Francisca S.N. Taveira, Tamara P. Kondratyuk, John M. Pezzuto, Fernão C. Braga
2014 Revista Brasileira de Farmacognosia  
Zingiberaceae COX-1 and -2 NF-κB Labdane diterpenes A B S T R A C T Hedychium coronarium J. Koenig, Zingiberaceae, is a medicinal plant popularly used to treat inflammatory conditions in different countries. Three labdane diterpenes [isocoronarin D (1), methoxycoronarin D (2), ethoxycoronarin D (3)] and benzoyl eugenol (4) were isolated from rhizomes and their chemopreventive potential was evaluated using in vitro assays, namely the inhibition of NF-κB, COX-1 and -2, the induction of
more » ... ction of antioxidant response element (ARE), and the inhibition of cell proliferation. Diterpene 1 activated ARE (EC 50 57.6 ± 2.4 µM), while 2, 3 and 4 significantly inhibited NF-κB (IC 50 of 7.3 ± 0.3, 3.2 ± 0.3 and 32.5 ± 4.9 µM, respectively). In addition, 2 and 3 selectively inhibited COX-1 (IC 50 values of 0.9 ± 0.0 and 3.8 ± 0.0 µM, respectively). These data support the potential chemopreventive activity of constituents from H. coronarium rhizomes.
doi:10.1016/j.bjp.2014.08.002 fatcat:yf44qgmrvzccvaj2ggvsgi6cmu