Raised serum uric acid levels as an independent risk factor for the development of hypertension

Issac Mudumala, Abhilash, Varun Nl, Mai, K Sastry, Post Graduate, Senior Residents, Issac Mudumala, Varun Abhilash, K Mai, Sastry
2017 unpublished
Mudumala Issac Abhilash, NL Varun Mai, K.B.R. Sastry. Raised serum uric acid levels as an independent risk factor for the development of hypertension.. Raised serum uric acid levels as an independent risk factor for the development of hypertension. IAIM, 2017; 4(11): 37-46. Abstract Background: Raised serum uric acid has been reported to be associated with an increased risk of coronary heart disease and is commonly encountered with essential hypertension, even untreated hypertension, and type 2
more » ... diabetes, which are in turn associated with coronary heart disease. Aim: To estimate the levels of uric acid in patients with essential hypertension. To correlate the levels of uric acid with the severity of hypertension in newly detected hypertensive patients. To compare the levels of uric acid in hypertensives with that in non hypertensives so as to assess the role of uric acid as a risk factor for hypertension. Materials and Methods: This study was an age and sex matched prospective case control study. Matching for other confounding factors such as diet, alcohol and smoking was also done. The study was conducted during the period from September 2010 to September 2012 after obtaining the clearance from the Institutional Ethics Committee. Inclusion Criteria: Patients of age > 18 years, newly detected patients of essential hypertension and patients with essential hypertension on treatment. Exclusion Criteria: Patients with renal failure. Patients on treatment with drugs altering uric acid levels such as thiazides, loop diuretics, pyrazinamide and allopurinol. Lymphoproliferative or myeloproliferative disorders. Secondary hypertension and pregnancy induced hypertension. The study included a total of 142 patients of which 80 were cases (hypertensives) and 62 were controls (non hypertensives). Results: The range of the serum uric acid in cases was 1.40 to 11.30 mg/dl. In hypertensive males it was found to be from 1.40 to 11.30 mg/dl and in hypertensive females it was found to be from 2.70 to 11.10 mg/dl. The range of the serum uric acid in controls was 1.50 to 6.50 mg/dl. In hypertensive
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