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Aims The mechanism of the cardioprotective action of metformin is incompletely understood. We determined the role of metformin in cardiac fibrosis and investigated the mechanism. Methods and results Ten-week-old male mice (C57BL/6) were subjected to left ventricular pressure overload by transverse aortic constriction. Mice received metformin (200 mg/kg/day) or normal saline for 6 weeks. Metformin inhibited cardiac fibrosis (fibrosis area/total heart area: 0.6 + 0.3 vs. 3.6 + 0.9%, P , 0.01)doi:10.1093/cvr/cvq066 pmid:20200042 fatcat:nsyg7flepzbqde3ojehil33vpy