Diagnostic Accuracy of Multi-Parametric Magnetic Resonance Imaging for Differentiation of Benign and Malignant Lesions of Prostate Using Radiomics Analysis

Soheila Koopaee, Anahita Fathi Kazerooni, Mahyar Ghafoori, Mohamad Reza Alviri, Kamal Hoseini, Fakhereh Pashaei, Hamidreza Saligheh Rad
2019 Iranian Journal of Radiology  
The precise localization of epileptic foci is an unavoidable prerequisite for epilepsy surgery. Simultaneous EEG-fMRI recording has recently created new horizons to locate foci in patients with epilepsy and, in comparison with single-modality methods, has yielded promising results although it is still subject to a few limitations such as the lack of access to information between interictal events. This study assessed its potential added value in the presurgical evaluation of patients with
more » ... patients with complex source localization. Adult candidates considered ineligible for surgery on account of an unclear focus and/or presumed multifocality based on EEG underwent EEG-fMRI. Objectives: Adopting a component-based approach, this study attempted to identify the neural behavior of the epileptic generators and detect the components of interest to be later used as inputs in the GLM model, substituting the classical linear regressor. Methods: Nine IED sets from five patients were analyzed. These patients were rejected for surgery because of an unclear focus in two, presumed multifocality in one, and a combination of both in two of them. Results: Component-based EEG-fMRI improved localization in three out of four patients with unclear foci. In patients with presumed multifocality, component-based EEG-fMRI advocated one of the foci in five patients and confirmed multifocality in one out of five patients. In two patients, component-based EEG-fMRI opened new prospects for surgery. In these complex cases, component-based EEG-fMRI either improved source localization or corroborated a negative decision regarding surgical candidacy. Conclusion: As supported by the statistical findings, the developed EEG-fMRI method led to a more realistic estimation of localization than the conventional EEG-fMRI approach, making it a tool of high value in the presurgical evaluation of patients with refractory epilepsy. Abstract Background: Prostate cancer is the second most common cancer-related cause of death in men. Accurate diagnosis of prostate cancer plays an important role in decreasing mortality rates. European Association of Urology (EAU) suggests multiparametric MRI (mp-MRI) of the prostate as a noninvasive method to evaluate prostate lesions. To leverage the interbreeder variability in the interpretation of mp-MRI, computer-aided diagnostic (CAD) systems can be used for automatic detection and characterization of prostate lesions. Objectives: The goal of this article was to design a quantification method based on mp-MRI for the discrimination of benign and malignant prostatic lesions with MR imaging/transrectal ultrasonography fusion-guided biopsy as a reference for pathology validation. Methods: Mp-MR images, including T1-and T2weighted, diffusion-weighted imaging (DWI), and dynamic contrast enhancement imaging (DCE) MRI were acquired at 1.5T from 27 patients. Then, 106 ra-
doi:10.5812/iranjradiol.99135 fatcat:jp3edtbpwrhxvkn4zatqkk7fou