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The plant Aganosma dichotoma is widely used as traditional medicine in different aborigines which is supported by this investigation. It belongs to Apocynacae family. The aim of the study was to evaluate the methanolic extract of leaf of Aganosma dichotoma's different fractionates as anti-diarrheal agents. The methanolic extract of leaves of Aganosma dichotoma (400 mg/kg) exhibited very statistically significant anti-diarrheal activity with a 68.27 % reduction of diarrhea compared to thedoi:10.7897/2277-4572.036208 fatcat:lsjgfen3tbebpmrwzacrt6c5aa