Aqueous Extract of Phyllanthus amarus Schum & Thonn Leaves Attenuated the Alterations in Fluoxetine-Induced Anti-Oestrogenic Activity in Female Wistar Rats

Quadri Nurudeen, Phytomedicine, Toxicology and Reproductive Biochemistry Research Laboratory, Department of Biochemistry, University of Ilorin, Ilorin, Nigeria., Musa Yakubu, Phytomedicine, Toxicology and Reproductive Biochemistry Research Laboratory, Department of Biochemistry, University of Ilorin, Ilorin, Nigeria.
2020 Tropical Journal of Natural Product Research  
Introduction The ovaries, which are regularly found in pairs are the sites of production and periodical release of egg cells and are analogous to the testes in male individuals. 1 A number of different conditions, from cysts to tumours, genetic mutation in the DNA repair gene Breast Cancer Type 1 (BRCA1) and/or exposure to organic compounds including medications like fluoxetine can cause ovarian problems. 2 Fluoxetine (also known by the trade names; such as Prozac, Rapiflux, Seraphim,
more » ... Seraphim, Animex-On, Sarafem, Adofen, Ladose, Fontex, Deprex) and other selective serotonin reuptake inhibitors (SSRIs) are among the most prescribed sets of antidepressants used in the treatment of neurological disorders, such as anorexia and depression. 2 Administration of fluoxetine delays the onset of puberty by increasing the concentration of serotonin in the ovaries and consequently decreases the number of ova shed. A recent study reported that fluoxetine acts on the ovary or hypothalamo-pituitary axis, and subsequently causes modifications of the follicular development and ovulation. 3 Some plants that have been acclaimed to be possible alternative remedies for the management of female sexual dysfunction and enhancing fertility problems include: Cimicifuga racemosa (black cohosh), Glycyrrhiza glabra (licorice), Paeonia officinalis (white
doi:10.26538/tjnpr/v4i7.10 fatcat:2zow2viywze5tnshljgl3lja4u