In vivo PET imaging of neuroinflammation in familial frontotemporal dementia

Maura Malpetti, Timothy Rittman, Peter Simon Jones, Thomas Edward Cope, Luca Passamonti, William Richard Bevan-Jones, Karalyn Patterson, Tim D Fryer, Young T Hong, Franklin I Aigbirhio, John Tiernan O'Brien, James Benedict Rowe
2020 Journal of Neurology, Neurosurgery and Psychiatry  
IntroductionWe report in vivo patterns of neuroinflammation and abnormal protein aggregation in seven cases of familial frontotemporal dementia (FTD) with mutations in MAPT, GRN and C9orf72 genes.MethodsUsing positron emission tomography (PET), we explored the association of the distribution of activated microglia, as measured by the radioligand [11C]PK11195, and the regional distribution of tau or TDP-43 pathology, indexed using the radioligand [18F]AV-1451. The familial FTD PET data were
more » ... PET data were compared with healthy controls.ResultsPatients with familial FTD across all mutation groups showed increased [11C]PK11195 binding predominantly in frontotemporal regions, with additional regions showing abnormalities in individuals. Patients with MAPT mutations had a consistent distribution of [18F]AV-1451 binding across the brain, with heterogeneous distributions among carriers of GRN and C9orf72 mutations.DiscussionThis case series suggests that neuroinflammation is part of the pathophysiology of familial FTD, warranting further consideration of immunomodulatory therapies for disease modification and prevention.
doi:10.1136/jnnp-2020-323698 pmid:33122395 fatcat:ltycwvfesbht7hpvv72jzcivrq