Unpicking the Combination Lock for Mutant BRAF and RAS Melanomas

Bissan Al-Lazikani, Paul Workman
2013 Cancer Discovery  
Large-scale, unbiased combinatorial drug screening has been used to identify effective genotypeselective therapeutic combinations that show promising activity in preclinical models of mutant BRAF and RAS melanoma that are resistant to the clinical BRAF inhibitor vemurafenib. Cancer Discov; 3(1);
doi:10.1158/2159-8290.cd-12-0520 pmid:23319765 fatcat:72rfnitk5vdl7liu3u4epnyls4