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ADMIRE: analysis and visualization of differential methylation in genomic regions using the Infinium HumanMethylation450 Assay

Jens Preussner, Julia Bayer, Carsten Kuenne, Mario Looso
2015 Epigenetics & Chromatin  

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DNA methylation at cytosine nucleotides constitutes epigenetic gene regulation impacting cellular development and a wide range of diseases. Cytosine bases of the DNA are converted to 5-methylcytosine by the methyltransferase enzyme, acting as a reversible regulator of gene expression. Due to its outstanding importance in the epigenetic field, a number of lab techniques were developed to interrogate DNA methylation on a global range. Besides whole-genome bisulfite sequencing, the Infinium
more » ... thylation450 Assay represents a versatile and cost-effective tool to investigate genome-wide changes of methylation patterns.
doi:10.1186/s13072-015-0045-1 pmid:26628921 pmcid:PMC4666223 fatcat:uspz5qcrdjdaxkgvmgrf7s73l4
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Jens Preussner, Julia Bayer, Carsten Kuenne, Mario Looso. "ADMIRE: analysis and visualization of differential methylation in genomic regions using the Infinium HumanMethylation450 Assay." Epigenetics & Chromatin 8.1 (2015)