COMPARISON OF EFFICACY OF TAMSULOSIN AND SILODOSIN IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA: A PROSPECTIVE STUDY

Debie Ann Sam 1 *, Sreeja P.A 1, Dr. Karthikeyan Veerappasamy 1, Henan Habeeb P 1, Jibin K Jaleel 1, Dr. Pravin Dass 2
2019 Zenodo  
The objective of the study was to compare the efficacy of 0.4mg Tamsulosin and 8mg Silodosin once daily dosing in patients with Benign Prostatic Hyperplasia (BPH) treated for 4 weeks. A Prospective Observational study which included 91 men who all were newly diagnosed with Benign Prostatic Hyperplasia. Maximum Urinary flow Rate (Qmax), Voided Volume were measured as Uroflowmetric parameters for assessment at the beginning and after 1 month of therapy. International Prostate Symptom Score and
more » ... ymptom Score and Quality of Life were assessed before therapy, after 48 hrs and after 1 month of therapy. The mean age of patients ranged from 50-88 years. There was a sustained and Significant Improvement in International prostate symptom score (IPSS) and Quality of Life (QOL) in all patient groups during the study. On comparing, Silodosin is found have faster onset of action and improvement in quality of life. Orthostatic hypotension and Headache was significant adverse reaction seen in Tamsulosin and Silodosin respectively. None of the patients discontinued the drug due to side-effects. Silodosin is a selective drug of choice for the treatment of Benign Prostatic Hyperplasia. It is well tolerated and faster reduction the symptoms. KEYWORDS: Benign Prostatic Hyperplasia, Tamsulosin, Silodosin, Uroflowmetry, International Prostate Symptom Score (IPSS), Quality of Life.
doi:10.5281/zenodo.3265344 fatcat:jmiehtzy7nayle2boifd7l2s6q