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Human Congenital Infection With Trypanosoma cruzi Induces Phenotypic and Functional Modifications of Cord Blood NK Cells
2006
Pediatric Research
We studied the phenotype and activity of cord blood natural killer (NK) cells in newborns congenitally infected with Trypanosoma cruzi. We found that the proportion of CD56 bright NK cells was significantly decreased in cord blood from these newborns, suggesting they may have been recruited to secondary lymphoid organs. The remaining CD56 bright NK cells exhibited a defective ability in the production of interferon (IFN)-␥ following in vitro activation with interleukin (IL)-12 ϩ IL-2 or IL-12 ϩ
doi:10.1203/01.pdr.0000220335.05588.ea
pmid:16690951
fatcat:aw7e3xtexngndln5hz3jd5obay