A case of systemic lupus erythematosus with multiple nodular hyperplasia of the liver

Michifumi Kohno, Mikiya Satoh, Ryuji Matsuyama, Makoto Miyata
1987 Japanese Journal of Clinical Immunology  
A case of systemic lupus erythematosus with portal hypertension due to multiple nodular hyperplasia of the liver was reported. A 30-year-old female with systemic lupus erythema tosus for the past 7 years was admitted to Sapporo City General Hospital because of hematemesis. She had been receiving prednisolone (about 10 mg/day, as a maintenance dose) for over 4 years. Physical examination showed severe anemia and marked splenomegaly. En doscopic examination, computed tomography scan, echography
more » ... scan, echography and scintigraphy of her liver revealed esophageal varices due to portal hypertension. ON the 8 th hospital day, she was subjectted to splenectomy and esophageal transection. The pressure of her potal vein was 27 cmH2O in the operation. The surface of her liver was irregular shape. The surgical liver biopsy revealed multiple nodular hyperplasia of the liver. On the 23 rd hospital day, she was died owing to the failure of the sutures and sepsis. The relation ships between multiple nodular hyperplasia of the liver and nRNP antibody was discussed. Key words: systemic lupus erythematosus, multiple nodular hyperplasia of the liver, portal hypertention
doi:10.2177/jsci.10.91 fatcat:eogvb3udwjchhmsfhdfvdzqzii