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Diabetes mellitus is categorized as a major metabolic disease. Hyperglycemia is the populest mediator. The oxygen radicals' production or the peroxide production in the mitochondria is preceded as a possible mechanism. TGF-beta is characterized as the main protagonist. TGF-b is a molecular mediator with adherent and hypertrophic properties in diabetic nephropathy. 20 Balb/c male and female mice were used. They were separated in two age groups, one of 4 weeks old (childhood, n= 10) and one of 6doi:10.17265/2328-2150/2016.01.001 fatcat:4do727nmqjcwtjjniebnw26wmm