ABO phenotype-protected reproduction based on human specific α1,2 L-fucosylation as explained by the Bombay type formation

Peter Arend
2018 Figshare  
The metabolic relationships between the formation of the ABO(H) blood group phenotype and human fertility are evident in the (Oh) or Bombay blood type, which Charles Darwin would have interpreted as resulting from reduced male fertility in consanguinities, based on the history of his own family, the Darwin/Wedgewood Dynasty. The classic Bombay type occurs with the extremely rare, human-specific genotype (h/h; se/se), which (due to point mutations) does not encode the fucosyltransferases 1(FUT1)
more » ... ransferases 1(FUT1) and FUT2, representing the basis for ABO(H) phenotype formation on the cell surfaces and plasma proteins, involving the neonatal immunoglobulin M. In fact, poor fucosylation of plasma proteins explains the polyreactivity of the Bombay phenotype IgM molecule, exhibiting pronounced isoagglutinin reactivities, dominated by a strong complement-binding anti-H. This polyreactive, aggressive IgM molecule highly suggests induction of ADCC and/or complement-mediated cytotoxicity via overexpressed glycosidic bond sites against embryogenic stem cell-to-germ cell transformation, depending on complementary glycan formations.
doi:10.6084/m9.figshare.1409398.v460 fatcat:uujhh36wt5gerla2lcxgrnhnou