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Recent MRI studies have demonstrated that the relative orientation of white matter fibers to the B 0 field significantly affects measurement. In this work, the origin of this effect was investigated by measuring R 2 and in multiple orientations and fitting the results to magnetic susceptibilitybased models and magic angle-based models. To further explore the source of magnetic susceptibility effect, the contribution of tissue iron to the orientation dependent contrast was investigated.doi:10.1016/j.neuroimage.2013.01.051 pmid:23376494 pmcid:PMC3638902 fatcat:ns74ughxzrej3jpzjy4nrexyd4