Computertomographische Analyse der ossären Mikroarchitektur mit räumlichem Bezug zu einem osteochondralen Defekt – Entwicklung einer distanzabhängigen Darstellungsmethode [article]

Lena Westermann, Universitätsbibliothek Der FU Berlin
2019
The biomechanical functionality of bones is, among other things, based on their microarchitecture. There is ongoing and intensiv research on the influence of bone architecture on the pathogenesis and the clinical evaluation of diseases such as osteoporosis, rheumatoid arthritis or metabolic diseases as well as its role in the development of pharmacological and invasive interventions. One such intervention, often first tested in animal models, is the implantation of biomaterial-based implants
more » ... l-based implants and osteosynthesis materials, designed to improve bone healing. In both cases a solid integration of the implant into the bone and supportive interactions between implant material and surrounding tissue is fundamental to therapy success. This thesis elaborates a way to assess bone microarchitectural parameters such as BV/TV, Tb.Th, Th.N and bone density in relation to a specific starting point – in this case a defect – and evaluate its influence clearly on all spatial dimensions. To this purpose, a well-established procedure was first applied on individual ROIs in specific spatial positions to the defect. Because this method was insufficient to properly characterize the architecture an algorithm was developed, that enables us to clearly visualize the distribution of trabecular parameters throughout the sample with respect to their spatial positioning to the defect. The two-dimensional representation obtained comprises three quantitative forms of information: (1) Distance of the parameter to the starting point, (2) height of the considered parameter within the sample and (3) quantity of considered pixels at that position. This approach to summarize three dimensional information into a two dimensional graphic allows us to offer a clear and intuitiv visualiation of bone microarchitecture in relation to the distance from the defect while retaining a high density of information in the same visualiation. It enables us an improved evaluation of interactions between implants and surrounding bone without using ROIs, only depending on [...]
doi:10.17169/refubium-25870 fatcat:nbxkriwfkjanheqeeumacyd32u