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Elevated production and excretion of neopterin indicate activation of cell-mediated immunity, since neopterin is produced in large quantities by human macrophages after stimulation with interferon gamma. In 21 patients, aged 9 to 19 years, with Crohn's disease, urinary neopterin was measured on a total of 135 consecutive followup visits. Additionally, a large panel of anamnestic, clinical and laboratory data were obtained at every visit. Both the first visit da ta set (21 records) and thedoi:10.1515/pteridines.19184.108.40.206 fatcat:yhu24363o5b4no25gg67senggy