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Cancer-induced bone pain (CIBP) is a common complication in many patients with malignant tumors, and seriously affects their quality of life. Recent studies have implicated reactive oxygen species (ROS) in the perception and regulation of pain through the spinal cord, indicating their possible involvement in CIBP as well. NADPH oxidases (NOX) generate ROS such as H2O2, superoxide anion, nitric oxide etc. as byproducts of oxidative phosphorylation. In this study, we will analyze the expressiondoi:10.21203/rs.2.24002/v1 fatcat:dcarnozbh5bffaj5cuisip4kuu