Nostocine A Derivatives as Human DNA Topoisomerase II-alpha Inhibitor

Chita Ranjan Sahoo, Sudhir Kumar Paidesetty, Rabindra Nath Padhy
2020 Indian Journal of Pharmaceutical Education and Research  
Due to heavy morbidity and mortality from cancer, the designing of newer drugable molecules against breast cancer is the call of day. As, Schiff-base sulfonamides have been widely used in tumor treatments. Methods: Nostocine-sulfonamide (NS) Schiff-base molecules were designed with tools of bioinformatics against the target enzyme, human topoisomerase II-alpha (topo IIa) against breast cancer. The designed NS conjugates were assessed by RO5, ADMET and molecular docking. Results: Herein, these
more » ... alogues, NS-20b (Nostocine A-sulfaphenazole), 12a (Nostocine A-sulfisoxazole) and 16b (Nostocine A-sulfamethazineare) are N-heteroaryl substituted sulfonamide moieties linked with pyrazolo[4,3-e][1,2,4]triazine of Nostocine A. Conclusion: These derivatives would act as potent inhibitors of topo IIa for breast cancer.
doi:10.5530/ijper.54.3.120 fatcat:rhptb6nft5dthgjjf7nbeqfhey