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Model-Informed Drug Development for Anti-Infectives: State of the Art and Future
2021
Clinical Pharmacology and Therapeutics
Model-informed drug development (MIDD) has a long and rich history in infectious diseases. This review describes foundational principles of translational anti-infective pharmacology, including choice of appropriate measures of exposure and pharmacodynamic measures, patient subpopulations, and drug-drug interactions. Examples are presented for state-of-the-art, empiric, mechanistic, interdisciplinary, and real-world evidence MIDD applications in the development of antibacterials (review of
doi:10.1002/cpt.2198
pmid:33555032
pmcid:PMC8014105
fatcat:v36327nlrvh2xoafvmsa63pwsy