ANTIDIABETIC EFFECTS OF PUMPKIN (CUCURBITA MOSCHATA DURCH) FLESH AND SEEDS EXTRACTS IN STREPTOZOTOCIN INDUCED MICE

Novarianti Marbun, Panal Sitorus, Siti Morin Sinaga
2018 Asian Journal of Pharmaceutical and Clinical Research  
Objective: The present study is to investigate the antidiabetic effect of pumpkin flesh and seeds ethanolic extracts in STZ-induced diabetic mice.Methods: The study begins with making the ethanolic extracts of pumpkin flesh and seeds and then evaluates the physicochemical characterization, phytochemical screening, and induced diabetic mice using STZ.Result: The physicochemical evaluation shows that the extracts had a good and high purity level, while the phytochemical screening showed both
more » ... ng showed both pumpkin flesh and seeds extracts have a various of phytoconstituents. The pumpkin flesh and seeds ethanolic extracts (dose level 150 mg/kg) showed a significant reduction of the blood glucose.Conclusion: Pumpkin flesh and seeds ethanolic extracts exhibited significant antidiabetes activity in STZ-induced mice.
doi:10.22159/ajpcr.2018.v11i2.22023 fatcat:57rc4xzx5bha3gdt2iqdsyhgfi