Molecular characterization of the bovine GHRL gene (Short Communication)

F. G. Colinet, D. Portetelle, R. Renaville
2009 Archives Animal Breeding  
Bovine ghrelin, a 27 amino acid peptide, has been identified in oxyntic glands of the abomasum. It is an endogenous ligand for growth hormone secretagogue receptor and stimulates food intake and growth hormone secretion. The bovine <i>GHRL</i> gene was completely sequenced and consists of five exons and four introns. Like mouse and human GHRL genes, we found that the bovine <i>GHRL</i> gene also contains a first non-coding exon of 21 bp. The bovine <i>GHRL</i> gene codes for 116 amino acid
more » ... de named preproghrelin which contains the ghrelin peptide and another peptide similar to obestatin. Sequence analysis revealed eight polymorphisms, which are located in the non-coding sequence of the gene.
doi:10.5194/aab-52-79-2009 fatcat:mkws3bjcbvgx5b6r2uorkx42rq