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Einfluß von 2-Desoxy-2.3-dehydro-N-acetylneuraminsäure auf Myxovirus-Neuraminidasen und die Replikation von Influenza- und Newcastle Disease Virus / Influence of 2-Deoxy-2,3-dehydro-N-acetylneuraminic Acid on Myxovirus-neuraminidases and the Replication of Influenza- and Newcastle Disease Virus

P. Meindl, G. Bodo, J. Lindner, P. Palese
1971 Zeitschrift für Naturforschung. B, A journal of chemical sciences  

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Neuraminidase of Influenza-A-Melbourne virus was competitively inhibited by 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. The inhibition constant (KI) was found to be 5.3 × 10-6 mol/l. The inhibition of different viral neuraminidases was found to vary considerably. The release of Influenza-A-Melbourne virus adsorbed to chick erythrocytes was strongly inhibited by 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. This substance also influenced the replication of neuraminidase containing viruses. The
more » ... tent of this inhibition was variable. In contrast, the replication of viruses not containing neuraminidase was not affected.
doi:10.1515/znb-1971-0812 fatcat:ltmgxw3vwndhtaprhfhdcdxfne
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P. Meindl, G. Bodo, J. Lindner, P. Palese. "Einfluß von 2-Desoxy-2.3-dehydro-N-acetylneuraminsäure auf Myxovirus-Neuraminidasen und die Replikation von Influenza- und Newcastle Disease Virus / Influence of 2-Deoxy-2,3-dehydro-N-acetylneuraminic Acid on Myxovirus-neuraminidases and the Replication of Influenza- and Newcastle Disease Virus." Zeitschrift für Naturforschung. B, A journal of chemical sciences 26.8 (1971) 792-797