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Essential Role for NHERF in cAMP-mediated Inhibition of the Na+-HCO3-Co-transporter in BSC-1 Cells
2001
Journal of Biological Chemistry
Prior studies have indicated a requirement for the PDZ domain-containing protein, Na ؉ /H ؉ Exchanger Regulatory Factor (NHERF), for protein kinase A (PKA)mediated inhibition of the renal basolateral Na ؉ -HCO 3 ؊ co-transporter (NBC). The present studies explore the potential mechanisms by which NHERF transduces cAMP signals to inhibit NBC. In BSC-1 cells, cells that express NBC but lack NHERF, 8-bromo-cAMP (100 M for 15 min) failed to inhibit transport until wild-type mNHERF-(1-355) was
doi:10.1074/jbc.m106153200
pmid:11535598
fatcat:3essbngw4jbr3j6tmfpwyxp64m